Cellular response to UV-A

Across TCGA cell cohorts, RNA activity of the Cellular response to UV-A pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPQ, CDKN1A, and CYFIP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CENPQ grouped by Cellular response to UV-A-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CENPQ →	+1.157	+1.705	.001	<.001	3	6
KIDNEY	CDKN1A →	-2.885	-1.628	<.001	<.001	3	5
LARGE_INTESTINE	CYFIP2 →	-1.483	-0.893	.008	.007	3	4
KIDNEY	ACD →	+0.861	+1.005	<.001	.001	3	4
KIDNEY	SESN1 →	-1.799	-1.455	<.001	.001	3	4
BREAST	NBPF14 →	-1.340	-1.122	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CENPQ by Cellular response to UV-A activity — SOFT_TISSUE

Explore this box plot interactively →