Cellular response to UV-A

Across TCGA cell cohorts, RNA activity of the Cellular response to UV-A pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCBP2, CFAP298, and NAXE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to UV-A activity versus PCBP2 in BLOOD_Leukemia (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PCBP2 →	+0.735	+0.213	<.001	.008	3	4
SOFT_TISSUE	CFAP298 →	+0.539	+0.239	.005	.009	2	4
STOMACH	NAXE →	+0.729	+0.330	.009	<.001	2	4
UPPER_AERODIGESTIVE_TRACT	EAPP →	+0.801	+1.948	.002	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	SUCLG1 →	+0.929	+2.017	.005	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	NDUFA11 →	+1.137	+2.060	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071492 vs PCBP2 — BLOOD_Leukemia

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