Cellular response to X-ray

Across TCGA patient cohorts, RNA activity of the Cellular response to X-ray pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FKBP7, THBS3, and TIMP2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to X-ray activity versus FKBP7 in OV (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FKBP7 →	+0.624	+0.069	<.001	<.001	3	9
UCEC	THBS3 →	+0.676	+0.144	<.001	<.001	3	8
OV	TIMP2 →	+0.645	+0.083	<.001	<.001	3	8
OV	VIM →	+0.517	+0.092	<.001	<.001	3	8
HNSC	CACNA2D1 →	+0.749	+0.091	<.001	<.001	3	8
PDAC	CNPY4 →	+0.358	+0.089	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071481 vs FKBP7 — OV

Explore this scatter interactively →