Cellular response to X-ray

Across TCGA patient cohorts, RNA activity of the Cellular response to X-ray pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HELLS, NCAPH, and DTL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to X-ray activity versus HELLS in PDAC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HELLS →	+0.621	+0.202	<.001	.001	3	5
PDAC	NCAPH →	+0.394	+0.201	.005	.001	3	5
PDAC	DTL →	+0.444	+0.173	.007	.004	2	6
BRCA	RAD54L →	+0.433	+0.211	.006	<.001	3	5
HNSC	CLCN2 →	+0.679	+0.437	<.001	<.001	3	4
OV	KIAA0513 →	-0.587	-0.474	.002	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071481 vs HELLS — PDAC

Explore this scatter interactively →