Cellular response to X-ray

Across TCGA patient cohorts, RNA activity of the Cellular response to X-ray pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TP53BP1_S1094, TP53BP1_S500, and TP53BP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to X-ray activity versus TP53BP1_S1094 in LUAD (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TP53BP1_S1094 →	+0.496	+0.269	<.001	<.001	3	8
LSCC	TP53BP1_S500 →	+0.658	+0.357	<.001	<.001	3	8
HNSC	TP53BP1 →	+0.266	+0.380	<.001	<.001	3	7
OV	NUCKS1 →	+0.795	+0.584	<.001	<.001	3	7
COAD	TP53BP1_S1114 →	+0.384	+0.441	<.001	<.001	3	6
HNSC	TP53BP1_S222 →	+0.572	+0.499	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071481 vs TP53BP1_S1094 — LUAD

Explore this scatter interactively →