Cellular response to ionizing radiation

Across TCGA patient cohorts, RNA activity of the Cellular response to ionizing radiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCN3, MAP1B_S614, and SMC4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to ionizing radiation activity versus RCN3 in OV (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RCN3 →	+0.592	+0.055	<.001	<.001	3	7
LUAD	MAP1B_S614 →	+1.531	+0.042	<.001	.001	3	7
LUAD	SMC4 →	+0.561	+0.047	<.001	<.001	3	7
BRCA	OMA1 →	-0.393	-0.037	<.001	<.001	3	7
COAD	CEP170 →	+0.332	+0.027	.001	<.001	3	6
COAD	CPT2 →	-0.369	-0.028	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071479 vs RCN3 — OV

Explore this scatter interactively →