Cellular response to ionizing radiation

Across TCGA cell cohorts, RNA activity of the Cellular response to ionizing radiation pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2L1, KLHL31, and KCNS3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCL2L1 grouped by Cellular response to ionizing radiation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BCL2L1 →	-0.841	-0.157	<.001	.002	3	7
BLOOD_Leukemia	KLHL31 →	+0.410	+0.366	.002	<.001	3	5
BLOOD_Myeloma	KCNS3 →	-0.325	-0.377	.006	.009	3	4
UPPER_AERODIGESTIVE_TRACT	PTCD3 →	+0.292	+0.221	.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	KDM1A →	-0.245	-0.308	<.001	<.001	3	4
KIDNEY	ITGA4 →	-0.221	-0.218	.007	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCL2L1 by Cellular response to ionizing radiation activity — LARGE_INTESTINE

Explore this box plot interactively →