Cellular response to radiation

Across TCGA cell cohorts, RNA activity of the Cellular response to radiation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINE2, SERPINE1, and C8orf88, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to radiation activity versus SERPINE2 in STOMACH (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SERPINE2 →	-4.284	-0.293	<.001	.002	3	5
BREAST	SERPINE1 →	-2.977	-0.161	.004	.002	3	4
BLOOD_Leukemia	C8orf88 →	-1.978	-0.130	.005	.007	3	4
KIDNEY	DAXX →	-0.557	-0.262	.001	.005	3	4
OESOPHAGUS	HIVEP3 →	-1.155	-0.146	<.001	.001	3	4
SOFT_TISSUE	ANKRD33B →	-1.997	-0.195	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071478 vs SERPINE2 — STOMACH

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