Cellular hypotonic response

Across TCGA patient cohorts, RNA activity of the Cellular hypotonic response pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA2, MYLK, and LMOD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular hypotonic response activity versus ACTA2 in LSCC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ACTA2 →	+1.042	+0.421	<.001	.001	3	8
BRCA	MYLK →	+0.927	+0.211	.001	<.001	3	8
LSCC	LMOD1 →	+1.050	+0.462	<.001	<.001	3	8
BRCA	LINC00702 →	+0.469	+0.242	<.001	<.001	3	7
LSCC	INMT →	+1.470	+0.472	<.001	<.001	3	7
LSCC	IRAG1 →	+0.883	+0.481	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071476 vs ACTA2 — LSCC

Explore this scatter interactively →