Cellular response to acidic pH

Across TCGA patient cohorts, RNA activity of the Cellular response to acidic pH pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSF1_S397, ST6GALNAC1, and TOM1L2_T164, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to acidic pH activity versus RSF1_S397 in CCRCC (Pearson r = -0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	RSF1_S397 →	-0.810	-0.065	<.001	.001	3	5
LSCC	ST6GALNAC1 →	+0.629	+0.100	<.001	<.001	3	5
HNSC	TOM1L2_T164 →	+0.436	+0.107	<.001	<.001	3	5
LSCC	PHF3_S1133 →	-0.289	-0.058	.002	.001	3	5
BRCA	CBFB →	-0.311	-0.039	.002	.009	3	5
CCRCC	UIMC1_S653 →	-0.206	-0.055	.009	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071468 vs RSF1_S397 — CCRCC

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