Cellular response to acidic pH

Across TCGA patient cohorts, RNA activity of the Cellular response to acidic pH pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDNRA, MCM3, and CAPN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to acidic pH activity versus EDNRA in LSCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EDNRA →	+0.809	+0.431	<.001	.005	3	6
BRCA	MCM3 →	-0.493	-0.630	.001	<.001	3	6
BRCA	CAPN2 →	+0.542	+0.534	.002	.003	3	5
LUAD	CD59 →	+0.670	+0.235	<.001	<.001	3	5
BRCA	E2F1 →	-0.962	-0.720	<.001	<.001	3	5
LSCC	SLC22A18AS →	+0.429	+0.595	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071468 vs EDNRA — LSCC

Explore this scatter interactively →