Cellular response to acidic pH

Across TCGA cell cohorts, RNA activity of the Cellular response to acidic pH pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OSBP2, SH3TC1, and C19orf48, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OSBP2 grouped by Cellular response to acidic pH-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OSBP2 →	-1.116	-1.379	.009	<.001	3	3
OVARY	SH3TC1 →	+1.715	+1.001	.002	.003	3	3
LARGE_INTESTINE	C19orf48 →	+0.527	+0.663	.008	.006	3	3
BREAST	INO80B →	+0.683	+0.576	<.001	.004	3	3
BONE	CPPED1 →	-1.863	-1.173	.002	.001	3	3
BLOOD_Lymphoma	NFATC4 →	-2.540	-1.705	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OSBP2 by Cellular response to acidic pH activity — SOFT_TISSUE

Explore this box plot interactively →