Cellular response to acidic pH

Across TCGA cell cohorts, RNA activity of the Cellular response to acidic pH pathway is significantly associated with the protein abundance of multiple proteins, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHP1, RAB11B, and PPIA, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to acidic pH activity versus CHP1 in LIVER (Pearson r = 0.67).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CHP1 →	+1.409	+0.313	.001	.006	2	12
UPPER_AERODIGESTIVE_TRACT	RAB11B →	+0.697	+0.201	.004	.003	2	12
LUNG_NSCLC_LUSC	PPIA →	-2.569	-0.350	.004	.009	3	11
LIVER	TBCA →	-2.473	-0.327	.001	<.001	3	10
SKIN	GNAS →	+0.905	+0.218	.001	<.001	2	10
CNS	MTHFD1 →	-1.327	-0.223	.001	<.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071468 vs CHP1 — LIVER

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