Cellular response to pH

Across TCGA patient cohorts, RNA activity of the Cellular response to pH pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1, RFC1_S368, and BAZ1B_S349, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to pH activity versus RFC1 in HNSC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RFC1 →	-0.222	-0.078	.005	<.001	3	5
LUAD	RFC1_S368 →	-0.605	-0.034	.001	.001	3	5
LUAD	BAZ1B_S349 →	-1.241	-0.063	<.001	<.001	3	5
LUAD	TOP2A_S1106 →	-1.017	-0.036	<.001	<.001	3	5
LUAD	TOP2A_S1247 →	-1.300	-0.048	<.001	<.001	3	5
LUAD	TTC39A →	+0.500	+0.030	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071467 vs RFC1 — HNSC

Explore this scatter interactively →