Cellular response to oxygen levels

Across TCGA patient cohorts, RNA activity of the Cellular response to oxygen levels pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NID2, GTF2F1, and PCOLCE, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to oxygen levels activity versus NID2 in BRCA (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NID2 →	+0.512	+0.027	<.001	<.001	3	8
GBM	GTF2F1 →	-0.268	-0.029	<.001	<.001	3	8
BRCA	PCOLCE →	+0.892	+0.028	<.001	<.001	3	8
BRCA	LUM →	+1.009	+0.024	<.001	<.001	3	8
BRCA	PROC →	+0.482	+0.024	<.001	<.001	3	8
OV	C4BPB →	+0.804	+0.040	.008	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071453 vs NID2 — BRCA

Explore this scatter interactively →