Cellular response to oxygen levels

Across TCGA cell cohorts, RNA activity of the Cellular response to oxygen levels pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXOSC2, NSMCE4A, and BRIP1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to oxygen levels activity versus EXOSC2 in SOFT_TISSUE (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	EXOSC2 →	-1.368	-0.333	.001	<.001	3	10
KIDNEY	NSMCE4A →	-0.605	-0.174	.008	.004	2	9
LUNG_SCLC	BRIP1 →	-1.168	-0.170	<.001	.002	3	7
BLOOD_Lymphoma	CTSA →	+1.338	+0.204	.004	.003	3	7
BLOOD_Lymphoma	RIOK1 →	-0.719	-0.147	.005	.009	3	7
BLOOD_Leukemia	SMARCC1 →	-0.621	-0.149	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071453 vs EXOSC2 — SOFT_TISSUE

Explore this scatter interactively →