Hematopoietic stem cell proliferation

Across TCGA cell cohorts, RNA activity of the Hematopoietic stem cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBBP4, MIIP, and ANKRD46, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hematopoietic stem cell proliferation activity versus RBBP4 in BREAST (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RBBP4 →	+1.093	+0.505	<.001	<.001	3	5
SKIN	MIIP →	+0.575	+0.331	.003	<.001	3	5
SOFT_TISSUE	ANKRD46 →	+1.169	+0.751	.002	.001	3	5
KIDNEY	SSR4 →	-0.785	-0.214	.004	<.001	3	4
LARGE_INTESTINE	PLOD3 →	-1.217	-0.389	.008	.008	2	5
LARGE_INTESTINE	CD63 →	-0.681	-0.419	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071425 vs RBBP4 — BREAST

Explore this scatter interactively →