Cellular response to purine-containing compound

Across TCGA patient cohorts, RNA activity of the Cellular response to purine-containing compound pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NUP98, GRAMD1A_S267, and GIMAP6, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to purine-containing compound activity versus NUP98 in HNSC (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NUP98 →	-0.137	-0.067	<.001	.004	3	6
COAD	GRAMD1A_S267 →	-0.295	-0.036	.001	<.001	3	5
HNSC	GIMAP6 →	+0.426	+0.086	.005	.001	3	5
CCRCC	GLIPR2 →	+0.374	+0.047	<.001	<.001	3	5
HNSC	SRRM2_S1444 →	-0.351	-0.073	<.001	<.001	3	5
HNSC	TCF20_S574 →	-0.325	-0.081	.005	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071415 vs NUP98 — HNSC

Explore this scatter interactively →