Cellular response to purine-containing compound

Across TCGA patient cohorts, RNA activity of the Cellular response to purine-containing compound pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCNT3, FBXO5, and FOXA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to purine-containing compound activity versus GCNT3 in HNSC (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GCNT3 →	-1.284	-0.606	.001	.009	3	5
BRCA	FBXO5 →	+0.524	+0.157	<.001	<.001	3	4
BRCA	FOXA1 →	-2.444	-0.231	<.001	<.001	3	4
BRCA	ARHGAP32 →	-0.790	-0.180	.003	.001	3	4
BRCA	TMEM45B →	-1.550	-0.196	<.001	<.001	3	4
BRCA	FAM174B →	-0.700	-0.145	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071415 vs GCNT3 — HNSC

Explore this scatter interactively →