Cellular response to purine-containing compound

Across TCGA cell cohorts, RNA activity of the Cellular response to purine-containing compound pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LSM12, PSME3, and PSMD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LSM12 grouped by Cellular response to purine-containing compound-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LSM12 →	-0.452	-1.356	.003	<.001	3	4
BLOOD_Leukemia	PSME3 →	-0.588	-0.940	.003	.002	3	4
BLOOD_Leukemia	PSMD2 →	-0.897	-1.199	<.001	<.001	3	4
LUNG_NSCLC_LUAD	PRSS53 →	-0.444	-0.830	.008	.004	2	4
LUNG_NSCLC_LUAD	CCNL1 →	-0.578	-0.607	<.001	.006	3	3
LUNG_NSCLC_LUAD	LACC1 →	+0.831	+1.108	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LSM12 by Cellular response to purine-containing compound activity — CNS

Explore this box plot interactively →