Cellular response to lipoprotein particle stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to lipoprotein particle stimulus pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL1, MKRN1, and LCN6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, METTL1 grouped by Cellular response to lipoprotein particle stimulus-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	METTL1 →	+0.153	+0.221	.001	.007	3	3
CNS	MKRN1 →	+0.218	+0.451	<.001	<.001	3	3
LIVER	LCN6 →	+0.206	+0.497	.003	.001	3	3
LIVER	MAST2 →	+0.376	+0.497	.007	.001	3	3
SOFT_TISSUE	IL23R →	-0.379	-0.511	.002	<.001	3	3
STOMACH	BCAT1 →	+0.135	+0.524	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

METTL1 by Cellular response to lipoprotein particle stimulus activity — SKIN

Explore this box plot interactively →