Cellular response to fatty acid

Across TCGA cell cohorts, RNA activity of the Cellular response to fatty acid pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP20, MRPL19, and GTF3A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CEP20 grouped by Cellular response to fatty acid-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CEP20 →	+0.508	+1.360	.004	<.001	3	4
OESOPHAGUS	MRPL19 →	+0.836	+1.014	<.001	<.001	3	4
OESOPHAGUS	GTF3A →	+0.783	+1.205	.002	.006	3	4
SOFT_TISSUE	TMBIM4 →	+1.198	+1.446	<.001	<.001	3	3
OESOPHAGUS	OTUD6B →	+0.703	+1.219	.004	<.001	3	3
BLOOD_Leukemia	DTD2 →	+0.585	+0.999	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CEP20 by Cellular response to fatty acid activity — SOFT_TISSUE

Explore this box plot interactively →