Cellular response to fatty acid

Across TCGA cell cohorts, RNA activity of the Cellular response to fatty acid pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLC1, WDCP, and SPDEF, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to fatty acid activity versus DLC1 in STOMACH (Pearson r = -0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DLC1 →	-3.276	-1.270	<.001	<.001	3	7
LARGE_INTESTINE	WDCP →	-0.682	-1.208	<.001	<.001	3	6
LARGE_INTESTINE	SPDEF →	+0.949	+0.810	.009	.004	2	7
STOMACH	CAMSAP2 →	-1.498	-1.290	<.001	.002	3	6
LIVER	TP53I11 →	+3.554	+1.601	.004	<.001	3	5
BLOOD_Lymphoma	RASGEF1B →	+1.676	+0.954	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071398 vs DLC1 — STOMACH

Explore this scatter interactively →