Cellular response to testosterone stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to testosterone stimulus pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DROSHA, TCTN1, and VASN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DROSHA grouped by Cellular response to testosterone stimulus-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DROSHA →	-1.136	-1.266	<.001	.001	3	4
OVARY	TCTN1 →	-0.959	-1.120	.001	.004	3	4
STOMACH	VASN →	-2.566	-1.346	<.001	.004	3	4
LUNG_NSCLC_LUAD	AZIN2 →	-1.019	-0.786	.002	.004	3	4
LUNG_NSCLC_LUAD	FAM183A →	-0.610	-0.820	.005	.001	3	4
OESOPHAGUS	MIB2 →	-1.558	-1.571	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DROSHA by Cellular response to testosterone stimulus activity — PANCREAS

Explore this box plot interactively →