Cellular response to testosterone stimulus

Across TCGA pan-cancer cohorts, RNA activity of the Cellular response to testosterone stimulus pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as UCEC and BRCA, show the opposite pattern, with lower activity in tumor tissue.

COAD, LUAD, and LUSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	Male	All	+0.068	<.001	11	view →
LUAD	Male	III,IV	+0.078	<.001	9	view →
LUSC	All	All	+0.068	<.001	8	view →
HNSC	Male	III,IV	+0.067	<.001	8	view →
UCEC	All	All	−0.059	.003	6	view →
BRCA	Female	All	−0.047	<.001	6	view →
STAD	All	IV	+0.149	.002	4	view →
LIHC	Female	All	−0.044	<.001	4	view →
CHOL	All	All	−0.061	.010	2	view →
BLCA	Female	III,IV	+0.042	.006	2	view →
KIRP	Male	All	−0.034	.001	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0071394–COAD

Open the COAD breakdown →