Cellular response to estradiol stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to estradiol stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ERCC6L_S820, UTP15, and HMGN4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to estradiol stimulus activity versus ERCC6L_S820 in LSCC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ERCC6L_S820 →	+0.757	+0.053	.003	<.001	3	6
LSCC	UTP15 →	+0.333	+0.047	<.001	<.001	3	6
LUAD	HMGN4 →	-0.420	-0.045	<.001	<.001	3	6
PDAC	UTP4 →	+0.284	+0.044	.002	.001	3	5
OV	HNRNPK_S216 →	+1.653	+0.064	<.001	<.001	3	5
PDAC	RFC2 →	+0.351	+0.053	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071392 vs ERCC6L_S820 — LSCC

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