Cellular response to estradiol stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to estradiol stimulus pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TFEC, PSAP, and MAP4K1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to estradiol stimulus activity versus TFEC in GBM (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TFEC →	-0.693	-0.311	.003	.007	3	4
CCRCC	PSAP →	-0.291	-0.539	.002	.001	3	4
GBM	MAP4K1 →	-0.306	-0.200	.001	.004	3	3
GBM	HAVCR2 →	-0.458	-0.203	.008	.004	3	3
GBM	TM6SF1 →	-0.389	-0.225	<.001	.001	3	3
GBM	OTULINL →	-0.600	-0.267	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071392 vs TFEC — GBM

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