Cellular response to estradiol stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to estradiol stimulus pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNA2, PTAR1, and LAMP1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCNA2 grouped by Cellular response to estradiol stimulus-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCNA2 →	-0.441	-0.333	<.001	<.001	3	9
LARGE_INTESTINE	PTAR1 →	+0.160	+0.215	.004	.006	3	5
URINARY_TRACT	LAMP1 →	-0.240	-0.223	.003	.005	3	5
SKIN	MSX2 →	-0.129	-0.242	.009	.001	3	5
SOFT_TISSUE	ADRB1 →	-0.254	-0.406	.005	.001	3	5
SKIN	HTR6 →	-0.167	-0.275	.004	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCNA2 by Cellular response to estradiol stimulus activity — LARGE_INTESTINE

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