Cellular response to estradiol stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to estradiol stimulus pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PEPD, S100A14, and ZNF589, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PEPD grouped by Cellular response to estradiol stimulus-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PEPD →	-0.779	-0.148	.007	.001	3	5
URINARY_TRACT	S100A14 →	+7.595	+0.260	<.001	.003	3	5
BREAST	ZNF589 →	-0.782	-0.152	.002	.003	3	5
URINARY_TRACT	TINAGL1 →	+6.880	+0.244	.002	.008	2	5
LARGE_INTESTINE	TLE6 →	-1.191	-0.164	.002	.006	3	4
BONE	MYCL →	+1.430	+0.282	.008	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PEPD by Cellular response to estradiol stimulus activity — SKIN

Explore this box plot interactively →