Cellular response to estrogen stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to estrogen stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SFRP1, EIF3H_S183, and LAMA4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to estrogen stimulus activity versus SFRP1 in PDAC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SFRP1 →	+0.687	+0.029	<.001	.006	3	6
BRCA	EIF3H_S183 →	-0.557	-0.055	<.001	<.001	3	5
OV	LAMA4 →	+0.458	+0.059	<.001	<.001	3	5
OV	ESRP2_S573 →	-0.551	-0.063	.001	.003	3	4
BRCA	MDC1_T966 →	-0.473	-0.029	.001	.007	3	4
BRCA	RPL6 →	-0.477	-0.052	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071391 vs SFRP1 — PDAC

Explore this scatter interactively →