Cellular response to estrogen stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to estrogen stimulus pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C17orf113, MIEF1, and ACP4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to estrogen stimulus activity versus C17orf113 in GBM (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	C17orf113 →	+0.607	+0.466	<.001	.003	3	4
LSCC	MIEF1 →	+0.280	+0.405	.001	.004	3	4
LSCC	ACP4 →	+0.453	+0.659	.003	<.001	3	4
LSCC	SPATA25 →	+0.388	+0.489	.001	<.001	3	4
LSCC	SLC27A5 →	+0.371	+0.494	<.001	<.001	3	4
LSCC	SNRPGP10 →	+0.397	+0.463	.008	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071391 vs C17orf113 — GBM

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