Cellular response to estrogen stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to estrogen stimulus pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNAI1, ZWINT, and ZNF23, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNAI1 grouped by Cellular response to estrogen stimulus-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SNAI1 →	-0.190	-0.101	.008	.003	3	4
KIDNEY	ZWINT →	+0.199	+0.092	.006	.002	3	4
STOMACH	ZNF23 →	-0.113	-0.084	.002	<.001	3	4
PANCREAS	MED24 →	-0.180	-0.083	.008	.003	3	3
BLOOD_Leukemia	FURIN →	+0.258	+0.098	.007	.006	3	3
BLOOD_Leukemia	CAMK2D →	-0.267	-0.187	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNAI1 by Cellular response to estrogen stimulus activity — BONE

Explore this box plot interactively →