Cellular response to estrogen stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to estrogen stimulus pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BARD1, CD22, and LOXL2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to estrogen stimulus activity versus BARD1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	BARD1 →	-0.950	-1.293	.001	.003	3	5
BLOOD_Lymphoma	CD22 →	+4.756	+1.349	<.001	<.001	3	4
BLOOD_Lymphoma	LOXL2 →	+2.739	+1.016	<.001	<.001	3	4
STOMACH	LTBP2 →	+2.217	+1.192	<.001	<.001	3	4
STOMACH	PHLDB2 →	+2.811	+0.917	.002	.001	3	4
STOMACH	ZBED8 →	+0.822	+1.168	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071391 vs BARD1 — UPPER_AERODIGESTIVE_TRACT

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