Cellular response to mineralocorticoid stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to mineralocorticoid stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGD6, FKBP1B, and CRYM, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to mineralocorticoid stimulus activity versus FGD6 in BRCA (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FGD6 →	+0.601	+0.213	.004	.006	3	4
PDAC	FKBP1B →	-0.294	-0.230	.003	.006	3	3
HNSC	CRYM →	-0.504	-0.916	.001	.001	3	3
COAD	CALM2P3 →	-0.463	-0.125	.001	<.001	3	3
PDAC	GJA8 →	-0.024	-0.353	.001	.002	3	2
PDAC	RAB3C →	-0.474	-0.242	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071389 vs FGD6 — BRCA

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