Cellular response to glucocorticoid stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to glucocorticoid stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYGL, HACD2, and ALDH3B1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to glucocorticoid stimulus activity versus PYGL in BLOOD_Leukemia (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PYGL →	+2.531	+0.177	.001	<.001	3	5
SOFT_TISSUE	HACD2 →	-0.742	-0.218	.002	<.001	3	4
BLOOD_Leukemia	ALDH3B1 →	+2.205	+0.195	<.001	<.001	3	4
BLOOD_Leukemia	FNDC3B →	+2.248	+0.235	<.001	<.001	3	4
BREAST	IGFBP3 →	+4.371	+0.196	<.001	.002	3	4
PANCREAS	HKDC1 →	+2.380	+0.296	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071385 vs PYGL — BLOOD_Leukemia

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