Cellular response to corticosteroid stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to corticosteroid stimulus pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C11orf80, DCLRE1C, and PRC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to corticosteroid stimulus activity versus C11orf80 in GBM (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	C11orf80 →	-0.472	-0.140	.004	.004	3	5
GBM	DCLRE1C →	-0.448	-0.175	<.001	<.001	3	4
GBM	PRC1 →	-0.306	-0.143	.002	<.001	3	4
LSCC	DCAF17 →	-0.440	-0.160	.004	.001	3	4
LSCC	KNL1 →	-0.733	-0.152	.002	.003	3	4
GBM	TIAL1 →	-0.327	-0.169	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071384 vs C11orf80 — GBM

Explore this scatter interactively →