Cellular response to corticosteroid stimulus

Across TCGA pan-cancer cohorts, RNA activity of the Cellular response to corticosteroid stimulus pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 60 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Cellular response to corticosteroid stimulus pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as BRCA and ESCA, show the opposite pattern, with higher activity associated with better survival.

UVM, BRCA, and ESCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.283	0.704	<.001	101	view →
BRCA	DFS	Tertile	III,IV	0.967	0.825	<.001	60	view →
ESCA	OS	Tertile	III,IV	0.638	0.340	.010	42	view →
OV	DFS	Median	IV	0.299	0.536	.002	36	view →
CHOL	DFS	Tertile	II,III,IV	0.086	0.540	.009	21	view →
THCA	OS	Quartile	II,III,IV	0.923	1.000	.018	18	view →
PAAD	OS	Tertile	All	0.396	0.649	.005	15	view →
LGG	DFS	Quartile	All	0.739	0.897	.006	13	view →
LUSC	OS	Median	IV	0.255	0.851	.021	12	view →
MESO	DFS	Tertile	IV	0.735	0.211	.001	12	view →
READ	OS	Median	II,III,IV	0.946	0.335	.003	10	view →
PCPG	DFS	Tertile	All	0.715	1.000	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0071384–UVM (DFS)

Open the UVM breakdown →