Cellular response to corticosteroid stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to corticosteroid stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD101, PPM1D, and ACYP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD101 grouped by Cellular response to corticosteroid stimulus-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CD101 →	-1.201	-1.110	<.001	.007	3	4
URINARY_TRACT	PPM1D →	-0.871	-0.241	<.001	.003	3	4
SKIN	ACYP1 →	-0.883	-0.252	<.001	.002	3	4
KIDNEY	NFAT5 →	+1.090	+0.167	.007	.008	2	4
KIDNEY	TMEM43 →	+1.064	+0.228	.001	.004	2	4
LUNG_SCLC	SLC37A4 →	-1.071	-0.673	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD101 by Cellular response to corticosteroid stimulus activity — LUNG_SCLC

Explore this box plot interactively →