Cellular response to corticosteroid stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to corticosteroid stimulus pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBPL1, SLC35G2, and SUGP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to corticosteroid stimulus activity versus TBPL1 in SOFT_TISSUE (Pearson r = -0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TBPL1 →	-0.452	-0.190	.002	.004	3	5
STOMACH	SLC35G2 →	-2.480	-0.371	.006	.001	3	5
STOMACH	SUGP1 →	-0.997	-0.424	.004	<.001	3	5
LIVER	RHBDL1 →	+0.980	+0.273	.002	.008	3	4
LIVER	IL18 →	+2.992	+0.219	.009	.004	3	4
LIVER	H2AC6 →	+1.985	+0.282	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071384 vs TBPL1 — SOFT_TISSUE

Explore this scatter interactively →