Cellular response to steroid hormone stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to steroid hormone stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SORBS1, LRP1, and SERBP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to steroid hormone stimulus activity versus SORBS1 in CCRCC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SORBS1 →	+0.488	+0.025	<.001	.001	3	7
BRCA	LRP1 →	+0.402	+0.028	<.001	<.001	3	7
BRCA	SERBP1 →	-0.209	-0.029	.003	<.001	3	7
BRCA	FERMT2 →	+0.449	+0.027	<.001	<.001	3	6
BRCA	RSU1 →	+0.315	+0.032	.001	<.001	3	6
CCRCC	TPM1 →	+0.356	+0.018	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071383 vs SORBS1 — CCRCC

Explore this scatter interactively →