Cellular response to prostaglandin E stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to prostaglandin E stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLEKHO2, WIPF1, and MRC2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to prostaglandin E stimulus activity versus PLEKHO2 in COAD (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLEKHO2 →	+0.448	+0.035	<.001	<.001	3	9
OV	WIPF1 →	+0.599	+0.069	<.001	<.001	3	8
LSCC	MRC2 →	+0.604	+0.069	<.001	<.001	3	8
HNSC	DAB2 →	+0.402	+0.075	<.001	<.001	3	8
OV	ITIH1 →	+0.910	+0.062	<.001	<.001	3	8
LSCC	FYB1 →	+0.528	+0.065	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071380 vs PLEKHO2 — COAD

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