Cellular response to prostaglandin E stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to prostaglandin E stimulus pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL23AP25, PBLD, and C9orf72, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to prostaglandin E stimulus activity versus RPL23AP25 in OV (Pearson r = -0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPL23AP25 →	+0.358	+0.170	<.001	.004	3	3
UCEC	PBLD →	+0.541	+0.220	.004	.002	3	3
UCEC	C9orf72 →	+0.454	+0.192	<.001	<.001	3	3
UCEC	RPS16P5 →	+0.997	+0.229	.001	.004	3	3
UCEC	TRPM5 →	-0.337	-0.174	.005	.009	3	3
UCEC	PGR →	+1.344	+0.242	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071380 vs RPL23AP25 — OV

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