Cellular response to prostaglandin E stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to prostaglandin E stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UNC119B_S119, MTARC2, and MUC13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to prostaglandin E stimulus activity versus UNC119B_S119 in GBM (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	UNC119B_S119 →	+0.673	+0.317	<.001	<.001	3	4
UCEC	MTARC2 →	+0.574	+0.231	<.001	<.001	3	3
BRCA	MUC13 →	+1.916	+0.335	.001	<.001	3	3
OV	POF1B_S413 →	-1.146	-0.209	<.001	<.001	3	3
LSCC	SHANK3_S366 →	-0.741	-0.479	<.001	.005	3	3
UCEC	RPTOR_S859 →	-0.373	-0.318	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071380 vs UNC119B_S119 — GBM

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