Cellular response to prostaglandin E stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to prostaglandin E stimulus pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFIH1, TMEM126B, and MLLT11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IFIH1 grouped by Cellular response to prostaglandin E stimulus-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	IFIH1 →	-1.069	-0.802	.002	.002	3	3
KIDNEY	TMEM126B →	-0.647	-0.763	.006	.004	3	3
BREAST	MLLT11 →	-1.170	-0.824	.002	.003	2	4
STOMACH	RASGRP3 →	-2.306	-1.170	.003	.006	3	3
STOMACH	PIP4K2C →	-0.793	-1.009	.003	.003	2	4
CNS	RNF227 →	+0.769	+0.989	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IFIH1 by Cellular response to prostaglandin E stimulus activity — KIDNEY

Explore this box plot interactively →