Cellular response to prostaglandin E stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to prostaglandin E stimulus pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB4, PHLDB2, and IGFBP7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to prostaglandin E stimulus activity versus ZBTB4 in STOMACH (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZBTB4 →	+1.449	+0.280	.002	.004	3	6
BONE	PHLDB2 →	+1.858	+0.334	.002	<.001	3	6
OVARY	IGFBP7 →	+4.733	+0.344	<.001	<.001	3	6
LIVER	HCFC1R1 →	+1.380	+0.342	<.001	.003	2	6
LIVER	PBXIP1 →	+2.249	+0.456	<.001	<.001	3	5
LIVER	CDK13 →	+0.653	+0.318	.005	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071380 vs ZBTB4 — STOMACH

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