Cellular response to prostaglandin stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to prostaglandin stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST6GALNAC1, GULP1, and AKR1C2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to prostaglandin stimulus activity versus ST6GALNAC1 in BRCA (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ST6GALNAC1 →	+0.833	+0.288	.002	.007	3	4
UCEC	GULP1 →	+0.779	+0.236	.001	<.001	3	3
LSCC	AKR1C2 →	+2.382	+0.228	.001	<.001	3	3
UCEC	MAPK6P3 →	+0.784	+0.300	<.001	<.001	3	3
PDAC	PKHD1 →	-1.164	-0.502	.002	.003	3	3
OV	ADH1B →	+1.721	+0.149	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071379 vs ST6GALNAC1 — BRCA

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