Cellular response to prostaglandin stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to prostaglandin stimulus pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHRS11, ZC3H8, and C12orf75, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to prostaglandin stimulus activity versus DHRS11 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DHRS11 →	-0.755	-0.353	.004	<.001	3	5
LUNG_SCLC	ZC3H8 →	-0.469	-0.291	.003	<.001	3	5
BREAST	C12orf75 →	+1.554	+0.148	.003	.009	2	6
PANCREAS	PPP2R5A →	+0.680	+0.265	.001	.003	3	5
OESOPHAGUS	ZNF304 →	+0.703	+0.171	.004	.007	3	4
OESOPHAGUS	SLC35A5 →	+0.720	+0.247	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071379 vs DHRS11 — UPPER_AERODIGESTIVE_TRACT

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