Cellular response to luteinizing hormone stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to luteinizing hormone stimulus pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NELFB, SIDT2, and PHYH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NELFB grouped by Cellular response to luteinizing hormone stimulus-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NELFB →	+0.505	+0.182	.003	.004	3	4
SOFT_TISSUE	SIDT2 →	-1.966	-0.252	.002	.004	3	4
OESOPHAGUS	PHYH →	-1.778	-0.232	.001	.006	3	4
OESOPHAGUS	TMEM214 →	-1.000	-0.225	<.001	<.001	3	4
OESOPHAGUS	SNRPD1 →	+0.563	+0.157	.009	.003	3	4
OESOPHAGUS	LAMB1 →	-1.742	-0.152	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NELFB by Cellular response to luteinizing hormone stimulus activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →