Cellular response to follicle-stimulating hormone stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to follicle-stimulating hormone stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL_S795, VCL_Y822, and CNN2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to follicle-stimulating hormone stimulus activity versus VCL_S795 in LSCC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VCL_S795 →	+0.485	+0.076	<.001	.001	3	7
LSCC	VCL_Y822 →	+0.598	+0.071	<.001	<.001	3	7
OV	CNN2 →	+0.824	+0.103	<.001	<.001	3	7
COAD	TGFB1 →	+0.432	+0.062	.001	<.001	3	7
OV	FKBP7 →	+0.616	+0.127	<.001	<.001	3	6
CCRCC	FLT1 →	+0.562	+0.076	.004	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071372 vs VCL_S795 — LSCC

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