Cellular response to follicle-stimulating hormone stimulus

Across TCGA pan-cancer cohorts, RNA activity of the Cellular response to follicle-stimulating hormone stimulus pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher Cellular response to follicle-stimulating hormone stimulus pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and LIHC, show the opposite pattern, with higher activity associated with better survival.

STAD, KIRP, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.494	0.659	<.001	126	view →
KIRP	DFS	Median	All	0.779	0.925	<.001	117	view →
KIRC	DFS	Tertile	IV	0.733	0.487	.001	62	view →
COAD	DFS	Tertile	All	0.698	0.855	.002	43	view →
CESC	DFS	Median	All	0.394	0.655	<.001	32	view →
LGG	OS	Median	All	0.853	0.930	<.001	31	view →
MESO	OS	Tertile	II,III,IV	0.308	0.543	.011	25	view →
THCA	OS	Median	II,III,IV	0.811	1.000	.007	25	view →
LIHC	DFS	Tertile	III,IV	0.687	0.272	.004	22	view →
UVM	OS	Tertile	All	0.335	0.836	.021	21	view →
UCS	DFS	Tertile	IV	0.938	0.321	.024	18	view →
OV	DFS	Median	All	0.491	0.588	.006	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0071372–STAD (OS)

Open the STAD breakdown →